Beilstein J. Nanotechnol.2023,14, 329–338, doi:10.3762/bjnano.14.28
increasing the access to the target sites in the organism. This type of interaction can lead to NP-modulated endothelialleakiness (NanoEL). The most important factors determining NanoEL are the physicochemical properties of the NPs. NP-modulated endothelialleakiness can lead to the discovery of new
bidirectional vascular permeability, which may contribute to the formation of cancer metastases. In this review we are focusing on the effect of metal and polymeric NPs on mechanism and degree of induction of NanoEL, as well as on the benefits and risks of using NPs that induce endothelialleakiness.
Keywords
: endothelialleakiness; metal nanoparticles; NanoEL; nanotoxicity; vascular permeability; Review
Introduction
The vascular barrier is a highly selective boundary between blood and tissues. Its proper functioning is essential to maintaining homeostasis of the whole organism. Formed from mesodermal endothelial
PDF
Figure 1:
The main functions of endothelial cells.